Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, antimycobacterial activity and docking studies of L-proline derived hydrazones

Author(s): K. Satish Reddy, M. Ramesh, V. Srimai, K. Subhash Chandra Bose, Apuri Satyender*† and T. Parthasarathy*

In this paper, we describe the synthesis of new L-proline based hydrazones (3a-j) from easily accessible (S)-2- carbomethoxypyrrolidine hydrochloride. All the synthesized hydrazones were characterized by 1H NMR, mass and elemental analysis data. All the titled compounds were evaluated for anti-mycobacterial activity against Mycobacterium smegmatis mc2155 (ATCC 35797). The compounds 3b, 3d, 3f and 3g showed moderate activity. Compound 3h showed maximum activity against Mycobacterium smegmatis mc2155. Docking studies using Auto dock program version 4.2 revealed that compound 3h exhibited very good binding energy with minimum inhibition constant value


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