Methyl acrylate on treatment with 4-chlorobenzenethiol gave methyl 3-[(4- chlorophenyl)thio]propanoate 1. The latter on oxidation with hydrogen peroxide gave methyl-3- [(4-chlorophenyl)sulfonyl]propanoate 2. 3-[(4-chlorophenyl)sulfonyl] propane hydrazide 3 was prepared from methyl3-[(4-chlorophenyl)sulfonyl] propanoate 2 by reaction with hydrazine hydrate. A series of new hydrazones 4a-h were prepared from 3-[(4- chlorophenyl)sulfonyl]propanehydrazide. The structural elucidation of these compounds was based on their IR, 1H NMR, and MS spectral data. These compounds were also screened for their antimicrobial activity against four bacteria and two fungi and some of the compounds found to have promising activity.