Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, characterisation and biological evaluati on of some novel Schiff’sbases derived from halovinyl aldehyde and 4 -amino-5-(pyridin-4-yl)- 4 H -1,2,4-triazole-3-thiol

Author(s): J. H. Mansoory a and S. S. Rajput *b

A series of N-substituted phenyl succinimides and t heir halovinyl aldehydes derivatives (2,5-dichloro- 1-(substituted phenyl)-pyrrole-3,4-dicarbaldehyde) have been prepa red by using Vilsmeier-Haack reaction. 4-amino-5-( pyridin-4- yl)-4H-1,2,4-triazole-3-thiol has been synthesized from isoniazidein a series of reactions. Condensati on of halovinyl aldehydes and 1,2,4-triazolewith catalytic amount o f piperidine in methanolafforded a series of new Sc hiff’s bases.All these compounds were characterised by the ir spectral analysi


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