Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, characterisation and pharmacological activities of 1-acetyl/propyl- 3-aryl-5-(5-aryloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazolines

Author(s): K. S. Girisha, Balakrishna Kalluraya and Padmashree

Aseries of 1-acetyl/propyl-3-aryl-5-(5-aryloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized compounds were screened for their analgesic and anti-inflammatory activity and most of the compounds showed significant activity comparable with that of the standard drug.


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