Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, characterization and antibacterial activity of some new 3- (aryl)-1-(4-(quinolin-8-ylamino)phenyl)prop-2-en-1-one

Author(s): Himani N. Chopde , Jyotsna S. Meshram , Ramakanth Pagadala, Venkateshwarlu Jetti

1-(4-(quinolin-8-ylamino)phenyl)ethanone (1) was synthesized from 4-aminoacetophenone and 8-hydroxyquinoline in presence of anhyd. ZnCl2. New chalcones (2) were synthesized from 1-(4- (quinolin-8-ylamino)phenyl)ethanone (1) and aromatic aldehydes under basic conditions via Claisen-Schmidt condensation. The structures of synthetic compounds were established on the basis of analytical and spectral data. These compounds were screened for their antibacterial activity


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