Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis, characterization and Antibacterial Screening of aminomethylated derivatives of 7-azaspiro[4.5]decane-6,8-dione

Author(s): Sheela Joshia, Purti Bilgaiyana, Anju Das Manikpurib, Anju Pathaka, Kapil Vyasa

Novel series of Mannich bases of 7-azaspiro[4.5]decane-6,8-dione with intact imide moiety were synthesized for the first time from various sulfonamides and secondary amines. The structural characterization is made using elemental and spectral studies. All the newly synthesized Mannich bases are introduced for antimicrobial activity against the bacteria S.aureus, S.typhi and P.aruginosa. Mannich bases are found more potent than their parent sulphonamide

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