Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis, Characterization and Antibacterial Studies of Mixed Ligand Complexes of 2-phenyl-2-(o-tolylamino) Acetonitrile and 1,10-phenanthroline with Some Metal Ions.

Author(s): Mohammed HA Al-Amery, Aseel H Abad Al-Ameer

The bidentate, ligand L1=2-phenyl-2-(o-tolylamino) acetonitrile was prepared by the reaction of primiry amine (o-toluidine) with benzaldehyde in presence of potassium cyanide and acidic media. The metal ion complexes of mixed ligands L1 and L2 (1,10-phenanthroline) were prepared by condensation a solution mixture of [VO(ІІ), Cr(ІІІ), Mn(II), Fe(II), Co(II) Ni(II), Cu(ІІ), Zn(ІІ), Cd(ІІ) and Hg(ІІ)] metal salts with the ligands (L1 and L2) in absolute ethanol with stirring. The complexes were characterized by the Elemental Micro Analysis (C, H, N), Chloride Content, FT-IR, UV-Vis spectra, Thermal Gravimetric Analysis (TGA), flame atomic absorption, molar conductivity as well as magnetic susceptibility measurement. According to the obtained data the probable coordination geometries of these complexes were suggested as octahedral except VO(ІІ) complex was found as square pyramid. Some complexes were found to be non-electrolyte, others were found to be weak electrolyte. The antibacterial activity of the ligands and their metal ion complexes have been studied by screening against various microorganisms, Staphylococcus aureus, Bacillus subtilis (Gram-positive), Escherichia and Pseudomonas aeruginosa (Gram-negativre). Agar (well-diffusion method) was used to determine the activity. The metal ion complexes gave the formulae: [VOL1L2]SO4.3H2O, [ML1L2Cl(H2O)]Cl, Where M: (Fe(ІІ), Mn(ІІ) and Cu(ІІ)), [CrL1L2Cl2]Cl.2H2O,[CoL1L2Cl(H2O)]Cl.H2O, [ML1L2Cl2)]3H2O.Where M: (Ni(ІІ), Zn(ІІ), Cd(ІІ)) and [HgL1L2Cl2]H2O.

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