A series of five 1-(4-((E)-3-arylacryloyl) phenyl)-3,4 dibromo-1H-pyrrole-2,5-diones (4'- aminochalcone-based dibromomaleimides) was synthesized using maleic anhydride and paminoacetophenone as starting material. Furthermore, there has been some additional work investigating the effect of these derivatives on biological activity. Aiming to obtain novel compounds that exhibit biological activities. They were characterized using FTIR, 1H NMR, 13C NMR & elemental analysis. The compounds show antifungal and antibacterial (minimal inhibitory concentration) activities.