Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, characterization and antimicrobial activity of metal chelates of 2-(8-Quinolinol-5-yl)-amino methyl-3(4-methyl phenyl)-5-(phenyl)-pyrazoline

Author(s): B. N. Patel, P. S. Patel and V. G. Patel

Complexes of 2-(8-Quinolinol-5-yl)-amino methyl-3(4-methyl phenyl)-5-(Phenyl)-Pyrazoline with Cu(II), Mn(II) and Zn(II) have been synthesized and characterized using elemental analysis, IR spectra, PMR spectra, Reflectance spectra, Conductivity measurements and antimicrobial activity. These studies revealed that they are having octahedral geometry of the type [ML2(H2O)2]. The compounds show net enhancement in activity on coordination of metals with ligand but moderate activity as compared to standard drugs.


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