The piperidine ring is a structural feature of many alkaloids and drug  candidates and there were thousands of piperidine compounds mentioned in clinical and preclinical studies. The piperidine ring system is one of the commonest structural sub units in natural compounds. Several substituted piperidines display important biological properties like antiviral activity. We have used a simple and highly efficient method for the synthesis of 1-(4- chlorophenyl) piperidine-2,6-diones. The reaction was optimized by using various solvents with some modifications in reaction conditions. The synthesized compounds are a precursor for dichlorodialdehydes 1, 4-DHP. Characterization of all synthesized piperidine-dione derivatives was done by analytical technique such as FTIR, 1HNMR. The resulting compounds possess symmetrical structures  and have high yields. All the compounds were screened for antimicrobial activities.