Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, characterization and antioxidant activity of some 1,3,4-oxadiazoles carrying 4-(methylsulfonyl)benzyl moiety

Author(s): Sumangala Vittal, Boja Poojary, Punith Bansal, Chidananda Nandagokula, ArulMoli, Tangavelu and Shalini Shenoy

A series of new 2-[4-(alkylsulfonyl) benzyl]-5-substituted-1,3,4-oxadiazole (6a-l) have been synthesized from 4-(alkyl thio) phenyl actetonitrile (1) through a multi step reaction sequence. The structures of new compounds were established on the basis of their elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds were screened for their antioxidant activity.


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