In the present study, a series of ten chalcone derivatives were synthesized by Claisen-Schmidt condensation and evaluated for their antiulcer activity. Chalcones are a group of naturally occurring compounds and precursor of flavonoids, isoflavonoids and important constituents of natural products such as fruits, vegetables, spices, tea and soya based food stuff. The structures of the compounds were characterized by Infra-Red (IR), Proton Nuclear Magnetic Resonance (1H-NMR) and mass spectral analysis. All the chalcones were evaluated for their antiulcer activity by using albino rats and the activity was measured by using methanol induced gastric ulcer model. The results of the best synthesized chalcones suggested that the presence of electron releasing groups and halogen moieties on aromatic ring showed best antiulcer activity and it was measured in terms of % antiulcer activity.