Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, characterization and biological activities of Cd(II) complexes with hydrazide ligands

Author(s): O. W. Salawu and A. O. Abdulsalam

A series of new acid hydrazides have been synthesized by reaction of novel ligands Acetic acid (3- chloro – 4 – hydroxyl benzylidene )-hydrazide (A), Acetic acid (2 – nitro – benzaylidene )- hydrazide (B) with cadimium (II) bromide , These new complexes were characterized by elemental analysis, IR spectroscopy and UV spectral techniques. The changes observed between the FT-IR and UV-Vis spectra of the ligands and of the complexes allowed us to establish the coordination mode of the metal in complexes . The results suggest that the Schiff bases coordinate as univalent anions with their two dentate N, O donors derived from the carbonyl and azomethine nitrogen . This newly synthesized compounds have been tested against grampositive bacteria (Bacillus subtilis and Staphylococcus aureus) and gram-negative bacteria (E.coli and Salmonella typhi ) for their antibacterial activity.


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