Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, characterization and biological activity of novel 3-benzyl-2-phenyl- 4(5H)-(substituted phenylhydrazino)-1,3-oxazolidines derivatives

Author(s): Theivendren Panneer Selvam, Palanirajan Vijayaraj Kumar, Parthasarathi Ramu, Arumugam Siva Kumar

A series of some new 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines 6a-f derivatives were synthesized. The in vitro anti-bacterial and anti-fungal activities were determined by paper disk diffusion method. The minimum inhibitory concentrations (MIC) of the compounds were also determined by agar streak dilution method. Most of the synthesized compounds exhibited significant anti-bacterial and anti-fungal activities. Among the synthesized compounds 3-benzyl-2-phenyl-4(5H)-4'methoxyphenyl hydrazino-1, 3-oxazolidine (6d) and 3- benzyl-2-phenyl-4(5H)-4'acetamidophenyl hydrazino-1, 3-oxazolidine (6e) exhibited most potent in vitro antimicrobial activity against Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus luteus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Aspergillus niger and Candida albicans.


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