Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, characterization and biological activity of novel spiroheterocycles from isatin derivatives

Author(s): RamuP, Augustine Arul Prasad T, Scholastica Mary Vithiya, S. Arul Antony

Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivative (6), dehydration of (6) gave 3-phenacylidene-2-indolinone derivative (7). Reaction of (7) with sarcosine and acenaphthenequinone yield novel spirooxindole derivatives which are characterized by various spectral methods. The compounds were subjected to antibacterial and antifungal studies and the results are very promising.


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