Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis, characterization and biological activity of novel transition metal complexes of N-{[2-(pyridin 4-ylmethyl)hydrazinyl]carbonothioyl}thiophene- 2-carboxamide

Author(s): T. C. M. Yuvaraj, P. Parameshwara Naik, G. Krishnamurthy, T. V. Venkatesh, B. Chidananda

N-{[2-(pyridin-4-ylmethyl)hydrazinyl]carbonothioyl}thiophene-2-carboxamide and its metal complexes have been synthesized and the structure elucidated by elemental analysis, conductivity measurements, UV-Visible, FT-IR, 1H NMR and thermal analysis. The complexes were soluble in most of the organic solvents and were non-electrolytic in nature. The cobalt and nickel complexes posses tetrahedral geometry while that of copper complex have octahedral geometry. The antimicrobial activities of title compounds have been screened against Gram-positive and Gramnegative bacteria with comparing standard ciprofloxacin as reference. Antifungal activities against two different fungi have been evaluated and compared with Flucanazole as reference. Almost all complexes showed excellent activity against bacteria and fungi strains used. The MIC result showed comparable activity as standard drug. Obtained compounds also subjected to antioxidant activity and they show potent activity when compared with ligand.

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