Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis, characterization and biological activity of triazolothiadiazines bearing 2H-1,4-benzothiazin-3(4H)-onemoiety

Author(s): Janet Goveas, A. M. A. Khader, B. Kalluraya, Sana Sheik and K. R. Chandrashekar

A new series of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives (7) of 4-[(4-amino-5-sulfanyl-4H-1,2,4-triazol- 3-yl)methyl]-2H-1,4-benzothiazin-3(4H)-one (4), were synthesized from (3-oxo-2,3-dihydro-4H-1,4-benzothiazin-4- yl)acetic acid (3). The structures of all newly synthesized compounds were elucidated by elemental analysis, FT-IR, 1H-NMR and mass spectral data. Synthesized compounds were screened for their antioxidant and antibacterial activity and a few of them exhibited significant activity. Among the tested compounds, (3-oxo-2,3-dihydro-4H-1,4- benzothiazin-4-yl)acetic acid (3) posssess antibacterial activity comparable to that of streptomycin. However the activity decreased on derivatization of the acid group.

ankara escort
mobile bitcoin casino
Casumo no deposit bonus bitcoin nedir?