Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis, Characterization and Crystal structure Studies of 2-[(4-chlorophenyl)(1H-indol-3-yl)methyl]-1H-indole

Author(s): R. Anil Kumar, S. Naveen, T. O. Shrungesh Kumar, K. M. Mahadevan, M. N. Kumara and N. K. Lokanath

The title compound, 2-[(4-chlorophenyl)(1H-indol-3-yl)methyl]-1H-indole was synthesized in good yield by condensation reaction between commercially available indole and 4-chlorobenzaldehyde under constant stirring in glacial acetic acid as a catalyst and solvent. The product obtained was characterized by spectroscopic techniques and finally the structure was confirmed by X-ray diffraction studies. The compound crystallizes in the triclinic crystal system with the space group P-1 with unit cell parameters a = 7.4955(4) Å, b = 12.0832(7) Å, c = 13.7889(8) Å, α = 106.727(2)o, β = 103.691(2)o,γ = 96.829(2)o and Z=2. The crystal structure features a strong N-- H…O hydrogen bond with different packing motifs. In the crystal string N—H...π, C—H…π and C—H...Cl interactions occur, forming a three dimensional network.

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