Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, Characterization and Crystal Structures of [4-substituted(aryl)- piperazin-1-yl](thieno[2,3-c]pyridin-5-yl)methanone derivatives

Author(s): P. P. Shinoj Kumara, G. Krishnaswamya, P. A. Suchetana, S. Sreenivasaa, S. Naveenb, N. K. Lokanathc and D. B. Aruna Kumara

Four [4-substituted(aryl)-piperazin-1-yl](thieno[2,3-c]pyridin-5-yl)methanones, namely, 4-(methoxyphenyl)- piperazin-1-yl](thieno[2,3-c]pyridin-5-yl)methanone (1), 4-(fluorophenyl)-piperazin-1-yl](thieno[2,3-c]pyridin-5- yl)methanone (2), 4-(methylphenyl)-piperazin-1-yl](thieno[2,3-c]pyridin-5-yl)methanone (3) and 4-(3,4- dimethylphenyl)-piperazin-1-yl](thieno[2,3-c]pyridin-5-yl)methanone (4) were synthesized and characterized by FTIR, 1H NMR and LC-MS spectroscopic techniques. The single crystals of all the compounds were grown, and their molecular & crystal structures were determined by single crystal X-Ray diffraction. The molecular structure of all the compounds features an intramolecular hydrogen bond of the type C-H…N which closes into a S(6) motif. The crystal structures of these compounds display several secondary interactions of the type C-H…O, C-H…F, C-H…π and π…π, and the combination of these interactions results in adopting different supramolecular architectures. Three different structure directing C-H…O interactions in 1 builds a three dimensional architecture, while in 2, two C-H…F and one C-H…O interactions generate a three dimensional structure. Several C-H…π interactions give additional stability to the crystal structures of 1 and 2and have no structure directing features. Unlike 1 and 2, the supramolecular structures of 3 and 4are two dimensional networks formed by a combination of C-H…O and CH… π interactions. The C-H…π interactions in 3 and 4 are structure directing in nature and extends the one dimensional architecture formed by C-H…O interactions into two dimensional.


FIND ARTICLES
SCImago Journal & Country Rank
 
kız uzun zamandır masaj salonunda çalışıyor çok sulanan erkek oluyor ama porno izle bir türlü hiç birine vermiyor Ama sonunda genç paraya sıkışıyor ve bir porno resimleri sikiş için çok para teklif eden genç adama sonunda kabul ediyor ve evlerine giren amatör pornolar maskeli hırsız genç kadının odasındaki çekmecelerde para ararken kadının seksi iç sikiş çamaşırlarına denk geliyor Onları koklayarak yarağı taş gibi oluyor daha sonra genç porno fotoğrafları kadın odaya bir den bire girince hırsızı görüyor ve bağırmaya başlıyor Hırsız hızlıca porno hikayeleri kızın ağzını elleri ile kapatarak tam kızın kalçalarını kucağına alarak sevişiyor
ankara escort
mobile bitcoin casino
Casumo no deposit bonus bitcoin nedir?