Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis, characterization and evaluation of antimicrobial activity of a series of 1,2,4-triazoles

Author(s): Rajkumar Agrawal and S. S. Pancholi

A series of 4H-1,2,4-triazoles was synthesized by using aromatic acid precursors via conversion to corresponding hydrazides, then thiosemicarbazides and finally to 1,2, 4-triazole derivatives. The synthesized compounds were characterized through various instrumental techniques viz., FTIR, FT-NMR, and MS. All the compounds were tested against six different strains of bacteria and two different strains of fungi. Compound no.s 2, 3, 4, 7 & 8 showed remarkable activities against the test microorganisms. The MICs of the compounds were also determined and reported.

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