Synthesis, Characterization, Crystal structure and Hirshfeld Surface Analysis of (2-oxo-2H-pyridin-1-yl)-acetic acid hydrazide

Zabiulla; S. Naveen; S. V. Mamatha; Mahima Jyothi; N. S. Lingegowda; N. K. Lokanath; Shaukath Ara Khanum

Abstract

Synthesis, Characterization, Crystal structure and Hirshfeld Surface Analysis of (2-oxo-2H-pyridin-1-yl)-acetic acid hydrazide

Author(s): Zabiulla, S. Naveen, S. V. Mamatha, Mahima Jyothi, N. S. Lingegowda, N. K. Lokanath and Shaukath Ara Khanum

The title compound, (2-oxo-2H-pyridin-1-yl)-acetic acid hydrazide was synthesized in good yield by refluxing 2- hydroxypyridine with ethyl chloroacetate in the presence of K₂CO₃ in anhydrous acetone. The product obtained was characterized by spectroscopic techniques and finally the structure was confirmed by X-ray diffraction studies. The compound crystallizes in the monoclinic crystal system with the space group P2₁/_c with unit cell parameters a = 8.6789(4) Å, b = 10.4374(5) Å, c = 8.3596(4) Å, β = 92.873(3)^o and Z=4. The crystal structure features two strong N--H…O hydrogen bonds with different packing motifs. Hirshfeld surface analysis for visually analyzing intermolecular interactions in crystal structures employing molecular surface contours and 2D fingerprint plots have been used to examine molecular shapes.

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