Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, characterization, molecular docking and evaluation of antimicrobial, antiproliferative, and anti-inflammatory properties of new 4-biphenyl substituted thiazolyl-pyridin-2-amine derivatives

Author(s): Bettadapura Gundappa Krishna, Balladka Kunhana Sarojini, Umesha Kundapur, Chenna Govindaraju Darshanraj

4-Biphenyl substituted thiazolyl-Pyridin-2-amine derivatives were prepared by Suzuki coupling reaction, between N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-pyridin-2-amine and substituted phenyl boronic acids. The new compounds were subjected to, antibacterial, antiproliferative, anti-inflammatory and molecular docking studies. Among the compounds tested, N-[4-(4’-fluorobiphenyl-4-yl)-1,3-thiazol-2-yl]pyridine-2-amine and N-{4-[4’-(trifluoromethyl) biphenyl-4-yl]-1,3-thiazol-2-yl}pyridine-2-amine showed promising properties. The newly synthesized compounds were characterized by analytical, IR, 1H NMR, 13C NMR and LCMS.


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