Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, Characterization of β-amino Carbonyl Complexes via Mannich Reaction and Study of Their Antibacterial Activity

Author(s): Pratibha Raundal, Rahul Watpade, Poonam Patil, Jayraj Aher

The present report is concerned with the Synthesis of β amino carbonyl compounds via Mannich reaction. Mannich reaction of aromatic amine, aromatic aldehyde and aromatic ketone finally yield β amino carbonyl compound. The substituted group effect of aromatic amines and ketones were also discussed. Sulphamic acid used as catalyst. This β-amino ketone was react with metal acetate of Zn (II), Cu (II) form square planer complexes. Ligands and metal complexes obtained were well characterized on the basis of spectral measurement and elemental analysis. New metal complexes were tested for antibacterial activity against different bacteria.


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