Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis of and characterization of a- aminophosphonates of fluorinated pyrazole imines using triethyl phosphite and TMSCl

Author(s): Deepak R. Nagargoje, Priyanka G. Mandhane, Sunil B. Bhagat, Namdev M. Chavan, Pravin V. Badadhe, and Charansingh H. Gill

A series of α-aminophosphonates (5a-j) have been synthesized from fluorinated pyrazole imines (3a-j) and triethyl phosphite using TMSCl as a catalyst by both conventional and under ultrasound irradiation conditions. The results showed the beneficial effect of the ultrasound irradiation on reaction which helps in shortening of the reaction time as well as smooth increase in the yield of products. The title compounds were characterized by physicospectral techniques like mass, IR and NMR spectra.

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