Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis of Efavirenz by an innovative cost effective cyclisation process

Author(s): Havale Shrikant Hanumantappa*, S. Venkat Rao, K. Na lini Mohan and Bhawani Singh

The present invention relates to a novel process fo r the preparation of (4S)-6-chloro-4-(cyclopropylet hynyl)-1, 4- dihydro-4-(trifluoromethyl)-2H-3, 1-benzoxazin-2-on e (Efavirenz) of Formula I with simple and commerci ally available urea.


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