Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis of new acyclic C-nucleosides and their oxadiazolenes as antimicrobial agents

Author(s): Adel A. H. Abdel-Rahman, Shafey G. Donia, Ashraf A. F. Wasfy, Aly A. Aly and Amaal Y. El-Gazzar

2-(N-Phthalimidomethyl)-4-chlorobenzylidene-1-[2-(2-mercapto-4-oxoquinazolin-3-yl)]-5-imidazole derivatives in addition to its sugar hydrazones were newly synthesized. The antimicrobial activity of the prepared compounds was evaluated against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Aspergillus niger and Candida albicans. The sugar hydrazones analogues were the highly active compounds.


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