Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis of novel 1,2,4-triazoles and their evaluation of 5-LOX inhibition and antimicrobial activity

Author(s): Mani Palla, Mahesh Palla, Praveen Choppara and Murthy Y. L. N.

A novel series of 1,2,4-triazoles were designed, synthesised and screened for their 5-LOX inhibition and antimicrobial activity. Among the tested compounds, compounds 6b and 6e showed potent 5-LOX inhibition with an IC50 of 6.98 and 8.0 μg/mL respectively, 6c and 6e were the promising compounds in antibacterial assay, where as compound 6c was found to be lead compound in antifungal assay.

ankara escort
mobile bitcoin casino
Casumo no deposit bonus bitcoin nedir?