Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis of novel (1-substituted benzenesulfonyl-1H-indol-5-yl)-(4- substituted piperazin-1-yl)-methanone derivatives as 5-HT6R ligands
Author(s): Ramakrishna V. S. Nirogi1, Prabhakar Kothmirkar1, 2, Anil K. Shinde1*, Jagadish Babu K1, K. R. Sastry1 and P. K. Dubey2(1H-Indol-5-yl)-(4-substituted piperazin-1-yl)-methanone derivatives, 6a and 6b were synthesized following the method given in Scheme - 1. Intermediates 6a & 6b were further reacted with substituted benzene sulfonyl chlorides to obtain the targeted compounds, (1- substituted benzenesulfonyl-1H-indol-5-yl)-(4-substitutedpiperazin-1-yl)-methanone derivatives 7a-m (Scheme - 2). All the synthesized compounds 7a-m were well characterized with spectral data and checked the in-vitro binding affinity towards 5-HT6 receptors. These compounds have shown mild to moderate potency towards serotonin 5-HT6 receptors and are considered as initial hits to do further modifications.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 25868
Der Pharma Chemica received 25868 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
DOWNLOADS
