Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis of novel heterocyclic compounds and their biological evaluation

Author(s): Avnish A. Patel, Arvind G. Mehta

Some new N4-[4,6-diarylsubstituted-2-pyrimidinyl]-6-methoxy-2-methyl-4-quinolinamine 3a-h were synthesized and studied for their microbicidal efficacy. These compounds were prepared from chalcones 1a-h on cyclized with guanidine nitrate, yielded 4-(substituted phenyl)-6- (substituted phenyl)-2-pyrimidinamine 2a-h and then refluxing with 4-chloro-6-methoxy-2- methylquinoline yield the title compounds 3a-h. All the compounds were characterized by elemental analysis and spectral studies. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.

ankara escort
mobile bitcoin casino
Casumo no deposit bonus bitcoin nedir?