Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis of novel pyrimidines thiazolopyrimidines, triazolopyrimidines and pyrimidotriazines as potent antimicrobial agent

Author(s): Ashraf M. Hamouda

A new seriesof 4-aryl-5-cyano thiouracilderivatives 4(a-c)was synthesized by reacting ethyl cyanoacetate, thiourea or substituted thiourea and aromatic aldehyde in presence of anhydrous potassium carbonate. The main target compound 4-(p-chlorophyll) -2- mercapto -6 -oxo-1,6- dihydropyrimidine-5- carbonitriles ( 4a) were reacted with chloroacetyl chloride , chloroacetonitrile or oxalyl chloride to give 2,5-dioxothiazolopyrimidines, 3-amino-5- oxothiazolopyrimidines and 2,3,5-trioxothiazolopyrimidines 5,6,7 respectively . Derivatives of 2-substituted benzylidne 3, 5-dioxothiazolopyrimidines 8a, b were prepared via reacting 4a with chloroacetic acid, aromatic aldehyde and anhydrous sodium acetate in presence of a mixture of acetic acid and acetic anhydride. Reacting compound 9 which was obtained by refluxing compound 4a with hydrazine hydrate , with formic acid or acetic anhydride give the respective triazolopyrimidines 10,11 .On the other handthe pyrimidotriazines 12,13 were obtained by the action of compound 9 with diethyl oxalate and ethyl bromoacetate in sodium ethoxide respectively. Reacting compound 9 with different aromatic aldehyde in glacial acetic acid gave a series of azomethene compounds 14(a-d). All the newly formed compounds are evaluated for their antimicrobial activity .It was found that some of the tested compoundshas variable activity against the selected strain.

ankara escort
mobile bitcoin casino
Casumo no deposit bonus bitcoin nedir?