Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis of some new biologically active chalcones and flavones

Author(s): S. S. Mokle, Y.B. Vibhute

New chalcones (3a-g) were synthesized from 2-chloro-6-methyl-quinoline-3-carbaldehyde (2) and halohydroxysubstitued acetophenones (1a-g) via Claisen-Schmidt condensation. Further new flavones (4a-g) were synthesized by oxidative cyclisation of chalcones (3a-g) using microwave as well as by conventional method. The structures of synthetic compounds have been characterized by analytical and spectral data. All the synthesized compounds have been evaluated for their antibacterial activity and studied the effect on seed germination of wheat (Triticum aestivum).

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