Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, Spectral Analysis and Antimicrobial Activity Studies of New Pyrazole Analogues
Author(s): Kishan N, Dileep Kumar A, Renuka N, Ajay Kumar K, Jayadevappa HPAn efficient procedure for the synthesis of substituted pyrazoles was developed. Claisen-Schmidt condensation of 2,4,5-trimethoxybenzaldehyde and substituted acetophenone in the presence of aqueous potassium hydroxide produced chalcones. An acid catalyzed cyclocondensation reaction of chalcones with 3-chlorophenylhydrazine hydrochloride produced substituted pyrazolines in good yields. The synthesized new compounds were characterized by spectral studies and elemental analysis; and some of the intermediate chalcones by single crystal X-ray diffraction studies and evaluated in vitro for their antimicrobial susceptibilities.
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Citations : 25868
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