Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis, spectral characterization and antimicrobial activity of α-hydroxyphosphonates

Author(s): G. Subba Reddy, Ch. SyamaSundar, S. Siva Prasad, E. Dadapeer, C. Naga Raju And C. Suresh Reddy

A simple and efficient method for the synthesis of α-hydroxyphosphonates (3a-j) was accomplished by the reaction of aldehydes and dialkylphosphitesusing 1,4-dimethyl piperazineas a catalystunder solvent-free condition at room temperature.Their chemical structures were characterized by IR, NMR (1H, 13C &31P), Mass spectral and elemental analysis. All the titled compounds were screened forInvitro antimicrobial activity.

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