Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, structural characterization, DNA binding activity studies of Cu(II), Ni(II) and Zn(II) metal complexes containing thiazole moiety

Author(s): M. Mariya Dorathi Anu, S. Damodar Kumar, S. Subramanian and S. Iyyam Pillai

The 2:1 Schiff base condensates of 1,2-di(thiophen-2-yl)ethane-1,2-dione with 1,4-diamino butane (L), respectively, were isolated and used to prepare Cu(II), Ni(II) and Zn(II) complexes. The resultant ligand complexes have been characterized from their elemental analysis, FT-IR, 1H NMR, 13C NMR, mass, UV-vis spectroscopic studies. The Schiff bases and their Cu(II), Ni(II) and Zn(II) complexes have been screened for binding behaviours towards calf thymus DNA. Binding of the complexes separately with Calf Thymus DNA is monitored using UV–vis spectral titrations, viscosity measurements and circular dichroic studies. The displacement of ethidium bromide (EB) bound to DNA by the complexes; in phosphate buffer solution (pH ~ 7.2) is monitored using fluorescence spectral titrations. The DNA binding constants reveal that all these complexes interact with DNA via intercalating binding mode with binding constants (Kb) of 5.4 x 104 M-1, 4.1 x 104 M-1 and 3.9 x 104 M-1 and Kapp of 6.3 x 105 M-1 6.0 x 105 M-1 and 5.8 x 105 M-1.


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