The present study investigated the effect of Cr(VI) in the kidneys of experimental rats and the protective effect of Dimocarpuslongan peel fruit as renal protector. Administration of 1 mLCr(VI) 1000 mg/L in experimental rats intraperitoneally increased all the biochemical parameters that were observed, including: MDA, urea, creatinine, SGOT and SGPT. Histologically, administration of Cr(VI) leads to swelling of tubule and severe necrosis in kidney. Pre-treatment with D.longan peel fruit antidote reduced the levels of biochemical parameters and oxidative stress parameters. The decreased levels of MDA, urea, creatinine, SGOT and SGPT were 51, 74%; 30,26%; 31,37%; 26,74% and 67,19% respectively. The pre-treatment with D.longan peel fruit also reduced the damage in kidney tissue, although there was still swelling in the tubules.