Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Topical anti-inflammatory activity of herbal gel formulation

Author(s): Parag A. Kulkarni, Shailesh Kewatkar Meghana D Lande, Mohini. A Phanse, and Pravin D. Chaudhari

The management and treatment of pain is probably one of the most common and yet the most difficult aspects of medicinal practice. This study evaluated a new herbal preparation containing extract from leaves of Vitex negundo (VN) for its topical anti-inflammatory activity against carrageenan induced edema, formalin test, anti-nociceptive effect. Gelling agent used in this study was 1% w/w concentration of carbopol-940 in the formulation. The studies were conducted on wistar rats of either sex (160-180 g). The change in oedema volume of the rat hind paw was measured. From the study we observed that the 1 % herbal formulation also potentiated the antiinflammatory and anti-nociceptive effect topically


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