Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Two new antileishmanial diketopiperazine alkaloids from the endophytic fungus Trichosporum sp.

Author(s): Ahmed M. Metwaly 1 * , Mohammed M. Ghoneim 1 and Arafa Musa 1,2

The fungus Trichosporum sp. is an endophytic fungus isolated from seeds of Trigonella foenum-graecum (Fabaceae). The endophytic fungus Trichosporum sp. has been subjected to chemical and biological inves tigations resulted in the isolation of two new diketopiperazi ne alkaloid isomers identified chemically as; (6-S) -3-(1,3- dihydroxypropyl)-6-(2-methylpropyl)piperazine-2,5-d ione and (6-R)-3-(1,3-dihydroxypropyl)-6-(2- methylpropyl)piperazine-2,5-dione ( 1 and 2 ). Three chiral centers in both of 1 and 2 were not identified due to lack of the isolated amounts. The isolated compounds wer e identified using different 1D and 2D NMR as well as IR and HR-MS techniques. The isolated compounds were exami ned for in vitro antileishmanial, antifungal, antib acterial and antimalarial activities. Compound 1 and 2 showed antileishmanial activities with IC 50 values of 96.3 and 82.5 μ g /ml, respectively


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