Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Ultrasonic studies of hyberdised drug molecules synthesized from nicotinamide in 70% DMF-Water at 300.15K

Author(s): Ujjwala D. Chapke, Bhushan P. Meshram, Pratibha S. Agrawal and Baliram N. Berad

The hybrid drugs have been synthesized by the condensation of nicotinamide and acid chlorides of salicylic acid, 5- nitro salicylic acid and ibuprofen as well as salicylaldehyde and vanillin in chloroform medium. The structures of all hyberdised drugs are confirmed on the basis of their spectral data. The ultrasonic velocity (U), viscosity(ƞ) and density (ρ) have been reported for these drug molecules within the concentration range 0.001M – 0.005M drug in 70% DMF-Water at 300K.From thesemeasured datadifferent acoustical parameters, such as adiabatic compressibility (β), relative association (RA), acoustic impedance (Z), relaxation time (τ) and intermolecular free length (Lf) were computed. The result have been analyzed and interpreted in terms of molecular interactions.


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