Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Use of Modern Technique for Synthesis of Quinoxaline Derivatives as Potential Anti-Virus Compounds

Author(s): Mahmoud A. Amin, Mohamed M. Youssef

The quinoxaline derivatives (4a,b) and (8) were synthesized by reaction of pyruvic acid and isatine with ophenylenediamine and 3,4-diaminophenol. The synthesized quinoxalines were reacted with formaldehyde and 4- aminobenzoic acid to yield Mannch products (5a,b) and (9). Condensation of (5a,b) and (9) with ophenylenediamine yield the quinoxaline benzimidazole derivatives (6a,b) and (10). All reaction carried out by using conventional method and heating by microwave.


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