A simple, precise and reproducible UV spectrophotometric method, Q‐value analysis method, have been developed and validated for the simultaneous estimation ofRabeprazole sodium andLevosulpiride. The method is based on the measurement of absorbance of Rabeprazole sodium and Levosulpirideat 260 nm which is the Isobestic point and 284 nm the λmax of Rabeprazole Sodium. The method obeyed Beer's law in the concentration range of 3-18 μg /ml forRabeprazole sodium and15-90 μg /ml for Levosulpiride. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method. The method was successfully applied to the determination of these drugs in pharmaceutical dosage form.