Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Visible spectrophotometric methods for the determination of duloxitine hydrochloride in bulk and dosage forms

Author(s): T. Srinivasa Reddy, U. Viplava Prasad, M. L. N. Acharyulu, B. V. Srinivas and C. S. P. Sastry

Two simple and sensitive visible spectrophotometric methods (method A and method B) have been reported for the determination of Duloxetiine hydrochloride (DXT) in bulk and dosage forms. Method A involves oxidation of DXT with Brucine in presence of Sodium meta periodate (IO4 -),l max 530 nm. Method B involves charge-transfer complex formation of DXT with in situ oxidized form obtained from Haematoxylin with Chloramine-T (CAT).The absorption Maximum were obtained at lmax (Method-A,530nm and 550nm for Method-B) . These methods are simple sensitive and reproducible with a recovery percent of 98.79±1.29(Method-A)and 99.17±0.69(Method-B) respectively and can be applied for the determination of (DXT) Both in bulk and Dosage Forms.


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