Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Zinc-morin complex improves pancreatic β-cell function in the HFD-STZ induced experimental type 2 diabetes

Author(s): V. Sendrayaperumal, S. Subramanian

Hyperglycemia induced oxidative stress plays a pivotal role in the initiation and progression of diabetes and its secondary complications. An increase in oxidative damage due to excessive generation of free radicals is associated with etiology of insulin resistance. The sensitivity of pancreatic β-cells to oxidative stress has been attributed to their low content of antioxidants compared with other tissues. Recently, we have synthesized, characterized a new zinc-morin complex and evaluated its antidiabetic potentialin HFD fed-low dose STZ induced type 2 diabetic rats. The present study was aimed to study the role of zinc-morin complex on hyperglycemia mediated oxidative stress in diabetic rats. Oral administration zinc-morin complex at a concentration of 5mg/kg body weight to diabetic rats for a period of 30 days resulted in significant improvement in pancreatic β-cellfunction, which in turn may be due to the increased level of metallothionein, a reservoir of zinc. Further, treatment with zinc-morin complex significantly improved the levels of enzymaticand non-enzymatic antioxidants and reduced the levels of lipid peroxides, nitric oxide, IL-1β and nuclear NF-κB p65 unit in pancreatic tissues of diabetic rats. Ultrastructural observationsfurther evidenced the pancreaticβ-cell protective nature of zinc-morin complex against oxidative damage.


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