Synthesis and characterization of 2-[(8-hydroxyquinolinyl)-5-aminomethyl]-3-(4-methoxyphenyl)-3(H)-quinazolin-4-one and its metal complexes with Cu(II), Ni(II), Mn(II), Co(II) and Zn(II) ion
By R. T. Vashi, S. B. Patel, H. K. Kadiya
ABSTRACT
Synthesis and characterization of 2-[(8-hydroxyquinolinyl)-5-aminomethyl]-3-(4-methoxy phenyl)-3(H)-quinazolin-4-one ligand called HAMQ (HL3) was studied. To prepare this ligand anthranilic acid was converted into 2-chloromethyl–3(4-methoxy phenyl)-3(H)-quinazoline-4-one. This compound was finally condensed with 5-amino-8-hydroxyquinoline. The transition metal complexes of Cu2+, Ni2+, Zn2+, Mn2+ and Co2+ of this ligand HAMQ were prepared and characterized by reflectance, NMR as well as IR spectroscopy, elemental analysis and magnetic measurements. The stoichiometry of the complexes has been found to be 1: 2 (Metal : ligand). The data suggested an octahedral geometry around Co2+, Ni2+ and Mn2+ complexes, a distorted octahedral geometry around Cu2+ and a tetrahedral geometry around Zn2+ have been proposed. These complexes have been tested for their antifungal activities
Keywords : Ligand, 8-hydroxyquinoline, IR and NMR spectral studies, magnetic moment, antifungal study.
