Benzimidazole in medicinal chemistry: An overview
By Manisha S Kedar, Nachiket S Dighe, Shashikant R Pattan, Deepak S Musmade, Dipak Thakur, Mayur Bhosale and Vinayak M Gaware
ABSTRACT
Benzimidazole is a bicyclic heterocycle system consisting of two nitrogen atoms and fused phenyl ring shows wide range of biological activities. Benzimidazole can be synthesized using o-phenylenediamine and carboxylic acid. Benzimidazole posses wide spectrum of biological activities like including antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present reviews attempted to gather the various developments in synthesis and biological activities of Benzimidazole derivatives.
Keywords : Benzimidazole, Biological activities, SAR, Total synthesis
