Bis-N-aryl-β-lactams: Vilsmeier Reagent as an efficient entity for the Synthesis via Alternate Cycloaddition Reaction and In vitro Biology
By Parvez Ali, Jyotsna Meshram, Vandana Tiwari, Rajendra Dongre, Javed Sheikh, Mudrika Ahemad
ABSTRACT
A practical synthesis of cis bis-β-lactams has been executed using Chloromethylenedimethylammonium chloride (Vilsmeier reagent), prepared easily from N, N-dimethylformamide and Phosphorus Oxychloride in situ. It works out as a versatile acid activator reagent for the direct [2+2] ketene–imine alternate cycloaddition of aromatic acetic acid and bis-imines in one-pot synthesis under mild reaction conditions proving as a high yielding protocol for bis-β-lactam. This protocol has been proved to be high yielding, efficient and cheap for cis bis-β-lactam synthesis. Some of physic-chemical properties associated with bis-β-lactam have been discussed.
Keywords : Vilsmeier, Azetidinones, Bis-β-lactams, Cycloaddition.
.
