Microwave assisted synthesis of N-substituted pyrimidines using AlCl3 as catalyst and their antimicrobial activities
By Mukesh M. Chavda, Manish J. Solanki, Jasmin J. Solnki, Chetna M. Rajyguru and Jatin M. Upadhyay
ABSTRACT
The three component condensation of an aldehyde, Substituted urea and 3-oxobutanamide in presence of catalytic amount of AlCl3 is disclosed for the synthesis of pyrimidine under solvent free microwave irradiation conditions. High yields are achieved even 1 g scale, while reaction times are considerably shortened compare to conventional method The antimicrobial activities of the pyrimidines (1a-t) are compared with those of known chosen standard drugs, viz. ampicillin, chloramphenicol, ciprofloxacin, norfloxacin and griseofulvin.
Key words: N-substituted, pyrimidines, AlCl3 catalyst, microwave irradiation, antimicrobial activity.
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