Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


1-[2-Substituted ethyl]-2-methyl-5-nitroimidazole derivatives, synthesis and antibacterial activities

Author(s): Mahmoud A. Al-Sha’er, Iman Mansi and Nancy Hakooz

In this study, seven diverse 1-[2-substituted ethyl]-2-methyl-5-nitroimidazole derivatives were synthesized by reacting various reagents with metronidazole, miscellaneous derivatives were synthesized that represent different scaffolds. The structure elucidation of the compounds was performed by IR, 1H-NMR, 13C-NMR and EI-MS. Antimicrobial activities of the compounds were examined and notable activities were observed. Although metronidazole had no activities against aerobic bacteria, synthetic benzene sulfonated metronidazole derivative (M1) exerts some inhibition on Staphylococcus aureus (MIC =250 μg/ml) and phenylacetamide metronidazole derivative (M3) exerts certain effect on Streptoccocus B (MIC = 187.5 μg/ml).