Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

2-[Benzyl(methyl)amino]propanedinitrile-New Building Block for Synthesis of Riociguat, a Pulmonary Hypertension Drug

Author(s): Kristine Nerkararyan, Karine , Nairi Gasparyan, Mariam Gharibyan, Mikayel Movsisyan, Frank Porstmann

Riociguat is a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension, is prepared via an efficient, non-infringing synthesis route from commercially available diethyl malonate via [N-Methyl(benzyl)amino]propanedinitrile.


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