Abstract

A comparative analyses effects of dexmedetomidine and etomidate on motor coordination and analgesia in rats

Author(s): Bilge Ozcan and Hülagü Barışkaner

Dexmedetomine selective alfa-2 adrenoreceptor agonist is nonnarcotic analgesic, hypnotic and sedative imidazole derivative agent. Etomidate is short acting hypnotic imidazole derivative anesthesic agent. In this study, we aimed to compare the analgesic and motor coordination effects of etomidate and dexmedetomidine in rats. In our study Wistar rats were used. The animals (n = 7) were randomly seperated 7 equal groups; saline group, etomidate group (2,5 mg/kg, 5 mg/kg, 10 mg/kg) and dexmedetomidine group (12,5 μg/kg, 30 μg/kg, 40 μg/kg). Pain measurement tests (von Frey test) and motor coordination (Rotarod) tests of 0th, 15th, 30th and 60th minutes were separately performed for each animal and datas were recorded. 120th minute added for dexmedetomidene and saline group. In von Frey tests etomidate's all doses were found statistically time-dependent significant differences to 0th minute (p<0,05). In the rotarod test 5 mg/kg and 10 mg/kg doses of etomidate were showed sedation at 15th and 30th minutes (p<0,05). In von Frey test dexmedetomidine was found at 15th, 30th and 60th minutes time-dependent significant differences to 0th minute (p<0,05). Also 30 μg/kg and 40 μg/kg doses were showed analgesic effects at 120th minute (p<0,05). Dexmedetomidine was found time and dose-dependent sedative effect in the rotarod test (p<0,05). In our study etomidate and dexmedetomidine were showed effective analgesic and sedative effects on rat models of mechanic pain and rotarod test. These two agents exerted time-dependent analgesic and sedative effects. In von Frey test at 60th minutes, the latency time of the dexmedetomidine higher dose was longer than that etomidate's higher dose. In rotarod test etomidate's higher dose was showed a significant difference at 15th minutes compared dexmedetomidine. However dexmedetomidine's 30 μg/kg dose was showed a significant difference at 30th minute compared to etomidate.

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