The present study is to compare the anti-inflammatory effect of Nicardipine with diclofenac sodium in rats and mice. The study was conducted using carrageenan-induced rat and mice paw inflammation models. Albino mice and wistar rats of either sex were divided in to four groups of six each. One of the groups was chosen as control, while the remaining three groups were drug treated groups. The control group received only normal saline intraperitoneally. While the other three groups received Diclofenac sodium (25mg/kg), Nicardipine (10mg/kg) and low dose Nicardipine (5mg/kg) intraperitoneally. After 30 minutes all the animals were injected with 0.1ml and 0.05 ml 1 % carrageenan respectively in to the animal hind paws. Paw volume measured by dipping in to the mercury plethysmograph. After carrageenan injection the time for number of licks were noted. Nicardipine in the dose of 10mg/kg was found to be equally effective with diclofenac sodium (25 mg/kg) in reducing edema in rats. In mice Nicardipine in the dose of (25 mg/kg) was found to be more effective than diclofenac sodium (25 mg/kg) in reducing pain and edema.